Brianna L Norton, David P HollandDepartment of galaxy harmony nc Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, NC, USAAbstract: Tuberculosis remains the world’s second leading infectious cause of death, with nearly one-third of the global population latently infected.Treatment of latent tuberculosis infection is a mainstay of tuberculosis-control efforts in low-to medium-incidence countries.Isoniazid monotherapy has been the standard of care for decades, but its utility is impaired by poor completion rates.
However, new, shorter-course regimens using rifamycins improve completion rates and campicon.com are cost-saving compared with standard isoniazid monotherapy.We review the currently available therapies for latent tuberculosis infection and their toxicities and include a brief economic comparison of the different regimens.Keywords: isoniazid, rifampin, rifapentine, tuberculin skin test, interferon-gamma release assay.